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标题: Practical High-Quality Electrostatic Potential Surfaces for Drug Discovery Us... [打印本页]

作者
Author:
captain    时间: 2019-11-13 09:05
标题: Practical High-Quality Electrostatic Potential Surfaces for Drug Discovery Us...
https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01129
Here, we present a graph convolutional deep neural network (DNN) model, trained on ESP surfaces derived from high quality QM calculations, that generates ESP surfaces for ligands in a fraction of a second.

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作者
Author:
sobereva    时间: 2019-11-13 11:43
粗略看了一眼,虽然作为ML范例是不错,但这种做法感觉实际意义不大,一个配体表面静电势计算也花不了多少时间,为了省那点时间还牺牲精度,导致后面更耗时的各种分析、模拟、讨论精度降低,很划不来。另外,此文也没有和MMFF94、TPACM4(快速近似计算RESP电荷)这些基于结构就能快速得到的原子电荷的静电势重现性进行对比,这不应该。




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