书名：Non-Covalent Interactions in Proteins 2nd Edition
链接：Non-Covalent Interactions in Proteins (worldscientific.com)
doi: 10.1142/12035
目录：
- Introduction:
- Some Historical Notes
- Overview of Protein Structural Elements and Basic Definitions
- Non-Covalent Interactions and Structure-Function Relationships in Proteins
- Van der Waals Interactions:
- Observation of van der Waals Interactions
- Nature of van der Waals Interactions
- Potential Functions for Application in Proteins
- Approximation for Polyatomic Systems
- Hydrogen Bonds:
- Nature of Hydrogen Bonds
- Geometry and Strength of Hydrogen Bond
- Hydrogen Bonds in Proteins
- Hydrogen Bonds and Protein Stability
- Hydrophobic Interactions:
- Nature of Hydrophobic Interactions
- Water
- Hydrophobic Effect
- Hydrophobic Interactions in Proteins
- Electrostatic Interactions:
- Debye-Hückel Theory
- Ion-solvent Interactions
- Calculation of Electrostatic Interactions in Proteins
- Ionisation Equilibria in Protein:
- Why Does One Need to Know Ionisation Equilibria?
- Basic Definitions
- Factors Determining Ionisation Equilibria in Proteins
- Combinatorial Problem
- Cooperative Ionisation
- Conformational Flexibility:
- Location Variation of Polar Hydrogen Atoms
- Examples for pH-Dependent Hydrogen Bonding
- Conformational Flexibility Involving Non-Hydrogen Atoms
- Protein States:
- Folded and Unfolded States
- Misfolded Proteins
- Metamorphic Proteins
- Intrinsically Disordered Proteins
- Modelling of Electrostatic Interactions in Unfolded Proteins:
- Spherical Model of Unfolded Proteins
- Size of the Dielectric Sphere
- Average Distance Between Charges
- Ionisation Equilibria in Unfolded Proteins
- Protein Stability:
- Definitions
- Kinetic Stability
- pH Dependence of Protein Stability
- Temperature Dependence of Protein Stability
- Thermal Stability of Proteins
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