Research Area:
The pathology of Alzheimer’s disease is linked to interactions between various types of
assemblies of amyloid-beta (Aβ) peptides (e.g., oligomers, channels and fibrils) and
neural cell membranes, which directly affect membrane integrity. In this project,
molecular dynamics (MD) simulations will be performed to unravel the details of the
molecular interactions between Aβ peptides and lipid membranes. The goal is to
understand the effect of membrane surfaces on the aggregation of Aβ. Aβ aggregation was
shown to be significantly accelerated by the presence of membranes, likely due to strong
electrostatic interactions between charged membranes and the Aβ peptide. To capture the
interaction of early Aβ oligomers with cellular membranes and the effect of the membrane
surface on the aggregation process, large-scale MD simulation of Aβ aggregation in the
presence of lipid bilayers will be performed and analyzed. This simulation study will
benefit from close collaborations with experimental groups.
A successful PhD thesis will be defended at the Heinrich Heine University Düsseldorf.
Specific Requirements:
- Excellent knowledge in (bio)chemistry or (bio)physics.
- Experience with computational chemistry and/or computational biophysics.
- Experience with Linux.
- Programming experience (C++, Python or Perl) is beneficial.
- Very good English skills.
Duration of stay: 48 M PhD
Work Place: Research Centre Juelich, Germany (near Cologne)
Starting Time: between September 2015 and February 2016
Language Course: A German language course will be offered parallel to the project.
Further information: Email: b.strodel@fz-juelich.de; www.fz-juelich.de/ics/ics-6/DE/strodel
Address for application: Dr. Birgit Strodel, Research Centre Juelich, Institute of Complex
Systems: Structural Biochemistry (ICS-6), 52425 Jülich, Germany. 作者Author: fantasticqhl 时间: 2015-1-14 18:47
补充一下，有效期到2月底！！！作者Author: koko 时间: 2015-1-18 23:33
看了，有几十万核计算资源？真是亮瞎了我眼。。。作者Author: fantasticqhl 时间: 2015-1-19 19:24